Joint Research Division Vascular Biology of the Medical Faculty Mannheim (CBTM), University of Heidelberg,
and the German Cancer Research Center (DKFZ-ZMBH Alliance)
Research articles of the Principal Investigators of the Joint Research Division Vascular Biology since 2003
2011
Urbich C, Kaluza D, Frömel T, Knau A, Bennewitz K, Boon R, Bonauer A, Döbele C, Böckel JN, Hergenreider E, Zeiher AM, Kroll J, Fleming I, and Dimmeler S. MicroRNA-27a/b controls repulsion and angiogenesis by targeting semaphorin 6A in endothelial cells. Blood, in press, 2011.
Jörgens K, Hillebrands JL, Hammes HP, and Kroll J. Zebrafish: A model for understanding diabetic complications. Exp Clin Endocrinol Diabetes, in press 2011.
Jörgens K, Schäker K, and Kroll J. Der Modellorganismus Zebrafisch in der biomedizinischen Grundlagenforschung: Anwendungen und Perspektiven in der vaskulären Biologie und Medizin. Dtsch Med Wochenschr, 136: 1865-1868, 2011.
Kaluza D, Kroll J, Gesierich S, Yao TP, Boon RA, Hergenreider E, Tjwa M, Rössig L, Seto E, Augustin HG, Zeiher AM, Dimmeler S, and Urbich C. Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J, 30: 4142– 4156, 2011.
Marciano, DK, Brakeman, PR, Lee, Ch-Z, Spivak, N, Eastburn, DJ, Bryant, DM, Beaudoin, GM, Hofmann I, Mostov, KE, Louis F, Reichardt, LF. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development, 138:2099-2109, 2011.
Stoll SJ, Bartsch S, Augustin HG, Kroll J. The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8. Circ Res., April 14, 2011.
Elisa Schleider, Sonja Stahl, Joycelyn Wüstehube, Ulrich Walter, Andreas Fischer, Ute Felbor. Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3 Neurogenetics 12:83–86, 2011.
2010
Eva Christina Thoma, Toni Ulrich Wagner, Isabell Paula Weber, Amaury Herpin, Andreas Fischer, Manfred Schartl.. Ectopic expression of single transcription factors directs differentiation of a Medaka spermatogonial cell line. Stem Cells and Development Nov 19, 2010 [Epub ahead of print].
Kutschera S, Weber H, Weick A, De Smet F, Genove G, Takemoto M, Prahst C, Riedel M, Mikelis C, Baulande S, Champseix C, Kummerer P, Conseiller E, Multon MC, Heroult M, Bicknell R, Carmeliet P, Betsholtz C, Augustin HG. Differential Endothelial Transcriptomics Identifies Semaphorin 3G as a Vascular Class 3 Semaphorin. Arterioscler Thromb Vasc Biol. Oct 14, 2010 [Epub ahead of print].
Wüstehube J, Bartol A, Liebler SS, Brütsch R, Zhu Y, Felbor U, Sure U, Augustin HG, Fischer A. Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A. Jul 13;107(28):12640-5, 2010.
Brütsch R, Liebler SS, Wüstehube J, Bartol A, Herberich SE, Adam MG, Telzerow A, Augustin HG, Fischer A. Integrin Cytoplasmic Domain-Associated Protein-1 Attenuates Sprouting Angiogenesis. Circ Res. Sep 3;107(5):592-601, 2010.
Thomas M, Felcht M, Kruse K, Kretschmer S, Deppermann C, Biesdorf A, Rohr K, Benest AV, Fiedler U, Augustin HG. Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation. J Biol Chem. Jul 30;285(31):23842-9, 2010.
Epting D*, Wendik B*, Bennewitz K, Dietz CT, Driever W, and Kroll J. The Rac1 Regulator ELMO1 Controls Vascular Morphogenesis in Zebrafish. Circ Res. Jul 9;107(1):45-55, 2010.
Breuninger S, Reidenbach S, Sauer CG, Ströbel P, Pfitzenmaier J, Trojan L, Hofmann I.. Desmosomal plakophilins in the prostate and prostatic adenocarcinomas: implications for diagnosis and tumor progression. Am J Pathol. May;176(5):2509-19, 2010.
Walter B, Krebs U, Berger I, Hofmann I. Protein p0071, an armadillo plaque protein of adherens junctions, is predominantly expressed in distal renal tubules. Histochem Cell Biol. Jan;133(1):69-83, 2010.
2009
Walter B, Berger I, Hofmann I. The proteins ARVCF and p0071 in renal cell carcinomas and their potential use in the diagnosis of renal tumors. Histopathology, DOI: 10.1111/j.1365-2559.2009.03444.x, 2009.
Coulpier F, Le Crom S, Maro GS, Manent J, Giovannini M, Maciorowski Z, Fischer A, Gessler M, Charnay P, Topilko P. Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers Glia, in press 2009.
Kroll J*, Epting D*, Kern K, Dietz CT, Feng Y, Hammes HP, Wieland T, and Augustin HG. Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularisation and sprouting angiogenesis. Am J Physiol Heart Circ Physiol, 296: H893-H899, 2009.
Anna M Laib, Arne Bartol, Abdullah Alajati, Thomas Korff, Holger Weber & Hellmut G Augustin. Spheroid-based human endothelial cell microvessel formation in vivo Nature Protocols, 4:1202 - 1215 , 2009.
Hofmann I, Schlechter T, Kuhn C, Hergt M, Franke W W.
Moll R, Sievers E, Hämmerling B, Schmidt A, Barth M, Kuhn C, Grund C, Hofmann I, Franke W W.
2008
Prahst C, Héroult M, Lanahan AA, Uziel N, Kessler O, Shraga-Heled N, Simons M, Neufeld G, and Augustin HG Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1 J. Biol. Chem. Vol. 283, Issue 37, 25110-25114, 2008
Becker R, Lenter MC, Vollkommer T, Boos AM, Pfaff D, Augustin HG and Christian S Tumor stroma marker endosialin (Tem1) is a binding partner of metastasis-related protein Mac-2 BP/90K The FASEB Journal Aug;22(8):3059-67, 2008
Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF & Kalluri R Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia Nature 453, 1117-1121, 2008
Korff T, Braun J, Pfaff D, Augustin HG, and Hecker M Role of ephrinB2 expression in endothelial cells during arteriogenesis: Impact on smooth muscle cell migration and monocyte recruitment Blood Vol. 112, No. 1, pp. 73-81, 2008
Alajati A, Laib AM, Weber H, Boos AM, Bartol A, Ikenberg K, Korff T, Zentgraf H, Obodozie C, Graeser R, Christian S, Finkenzeller G, Stark GB, Héroult M & Augustin HG Spheroid-based engineering of a human vasculature in mice Nat Methods. 5(5):439-45, 2008
Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, Kzhyshkowska J, Schledzewski K, Arnold B, Goerdt B Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology 47:1018 - 1031, 2008
Christian S, Winkler R, Helfrich I, Boos AM, Besemfelder E, Schadendorf D, Augustin HG. Endosialin (tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells. Am J Pathol. 172(2):486-94, 2008.
Goettsch W, Gryczka C, Korff T, Ernst E, Goettsch C, Seebach J, Schnittler HJ, Augustin HG, Morawietz H: Flow-dependent regulation of Angiopoietin-2 J Cell. Physiol. 214(2):491-503, 2008
Walter B, Schlechter T, Hergt M, Berger I, Hofmann I. Differential expression pattern of Protein ARVCF in nephron segments of human and mouse kidney.
Hofmann I, Kuhn C, Franke W W.
2007
Nacak TG, Alajati A, Leptien K, Fulda C, Weber H, Miki T, Czeplich FS, Waltenberger J, Wieland T, Augustin HG, Kroll J. The BTB-kelch protein KLEIP controls endothelial migration and sprouting angiogeneiss. Circ. Res. 100: 1155-1163, 2007
Shraga-Heled N, Kessler O, Prahst C, Kroll J, Augustin HG, Neufeld G. Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor. FASEB J. 21: 915-926, 2007
Fischer A, Steidl C, Wagner TU, Lang E, Jakob PM, Friedl P, Knobeloch KP, Gessler M. Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ. Res. 100: 856-863, 2007
Diez H, Fischer A, Winkler A, Hu CJ, Hatzopoulos AK, Breier G, Gessler M. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp. Cell Res. 313: 1-9, 2007
Franke W W, Schumacher H, Borrmann C M, Grund C, Winter-Simanowski S, Schlechter T, Pieperhoff S, Hofmann I.
2006
Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner K, Vajkoczy P, Augustin HG. Angiopoietin-2 sensitizes endothelial cells to TNF and plays a crucial role in the induction of inflammation. Nat. Med. 12:235-239, 2006
Korff T, Dandekar G, Pfaff D, Füller T, Goettsch W, Morawietz H, Schaffner F, Augustin HG. Endothelial ephrinB2 is controlled by microenvironmental determinants and associates context dependently with CD31. Arterioscl. Thromb. Vasc. Biol. 26: 468-474, 2006
Fiedler U, Christian S, Koidl S, Kerjaschki D, Emmett MS, Bates DO, Christofori G, Augustin HG. The sialomucin CD34 is a marker of tumor-associated lymphatic endothelial cells in human tumors. Am. J. Pathol. 168:1045-1053, 2006
Nacak TG, Leptien K, Fellner D, Augustin HG, Kroll J. The BTB-kelch protein LZTR-1 is a novel trans-Golgi network protein and is degraded upon induction of apoptosis. J. Biol. Chem. 281: 5065-5071, 2006
Krneta J, Kroll J, Alves F, Prahst C, Sananbenesi F, Dullin C, Kimmina S, Phillips DJ, Augustin HG. Dissociation of angiogenesis and tumorigenesis in activin and follistatin expressing tumors. Cancer Res. 66: 5685-5695, 2006
Athanasopoulos AN, Economopoulou M, Orlova VV, Sobke A, Schneider D, Weber H, Augustin HG, Eming SA, Schubert U, Linn T, Nawroth PP, Hussain M, Hammes HP, Herrmann M, Preissner KT, Chavakis T. The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms. Blood 107: 2720-2727, 2006
Rutenberg JB, Fischer A, Jia H, Gessler M, Zhong TP, Mercola M. Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development 133: 4381-4390, 2006
Hofmann I, Casella M, Schnölzer M, Schlechter T, Spring H, Franke W W.
Borrmann C, Grund C, Kuhn C, Hofmann I, Pieperhoff S, Franke W W.
Peitsch W K, Bulkescher J, Spring H, Hofmann I, Goerdt S, Franke W W.
2005
Scharpfenecker M, Fiedler U, Reiss Y, Augustin HG. The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J. Cell Sci. 118:771-780, 2005
Saharinen P, Kerkela K, Ekman N, Marron M, Brindle N, Lee GM, Augustin H, Koh GY, Alitalo K. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J. Cell Biol. 169:239-243, 2005
Müller SM, Terszowski G, Blum C, Haller C, Anquez V, Kuschert S, Carmeliet P, Augustin HG, Rodewald HR. Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture. Proc Natl Acad Sci USA 102: 10597-10592, 2005
ADDIN EN.REFLIST Kroll J, Shi X, Caprioli A, Liu HH, Waskow C, Lin KM, Miyazaki T, Rodewald HR, Sato TN: The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Mol. Cell. Biol. 25: 8531-8540, 2005
Fischer A, Klattig J, Kneitz B, Diez H, Maier M, Holtmann B, Englert C, Gessler M. Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol. Cell. Biol. 25: 8960-8970, 2005
Pyagay P, Heroult M, Wang Q, Lehnert W, Belden J, Liaw L, Friesel RE, Lindner V. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ. Res. 96:261-268, 2005
Peitsch W K., Hofmann I, Bulkescher J, Hergt M, Spring H, Bleyl U, Goerdt S, Franke W W.
2004
Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W, Thurston G, Augustin HG. The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103: 4150-4156, 2004
Martiny-Baron G, Korff T, Schaffner F, Esser N, Eggstein S, Marmé D, Augustin HG. Inhibition of tumor growth and angiogenesis by soluble EphB4. Neoplasia 6: 248-257, 2004
Hegen A, Koidl S, Weindel K, Marme D, Augustin HG, Fiedler U. Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements. Arterioscler Thromb Vasc Biol 24: 1803-1809, 2004
Krauss T, Pauer U, Augustin HG. Prospective analysis of placenta growth factor (PlGF) concentrations in the plasma of women with normal pregnancy and pregnancies complicated by preeclampsia. Hypertens. Pregnancy 22: 101-111, 2004
Goettsch W, Augustin HG, Morawietz H. Down-regulation of endothelial EphrinB2 expression by laminar shear stress. Endothelium 11:259-265, 2004
Stahl A, Wenger A, Weber H, Stark GB, Augustin HG, Finkenzeller G. Bi-directional cell contact-dependent regulation of gene expression between endothelial cells and osteoblasts in a three-dimensional spheroidal coculture model. Biochem Biophys Res Commun 322: 684-692, 2004
Wenger A, Stahl A, Weber H, Finkenzeller G, Augustin HG, Stark GB, Kneser U. Modulation of in vitro angiogenesis in a three-dimensional spheroidal co-culture model for bone tissue engineering. Tissue Eng. 10: 1536-1547, 2004
Korff T, Krauss T, Augustin HG. Three-dimensional spheroidal culture of cytotrophoblast cells mimics the phenotype and differentiation of cytotrophoblasts from normal and preeclamptic pregnancies. Exp. Cell Res. 297: 415-423, 2004
Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M. The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 18 : 901-911., 2004
Schlaeger TM, Schuh A, Flitter S, Fischer A, Mikkola H, Orkin SH, Vyas P, Porcher C. Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1 Mol. Cell. Biol. 24: 7491-7502, 2004
Fischer A, Klamt B, Schumacher N, Glaeser C, Hansmann I, Fenge H, Gessler M. Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome. Mamm. Genome 15: 711-716, 2004
2003
Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marme D, Augustin HG. Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first IgG-like loop and the EGF-like repeats. J. Biol. Chem. 278: 1721-1727, 2003
Füller T, Korff T, Killian A, Dandekar G, Augustin HG. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J. Cell Sci. 116: 2461-70, 2003
Veikkola T, Lohela M, Ikenberg K, Mäkinen T, Korff T, Saaristo A, Jeltsch M, Augustin HG, Alitalo K. Intrinsic versus microenviromental regulation of lymphatic endothelial cell phenotype and function. FASEB J. 17: 2006-2013, 2003
Scheuffler KM, Drevs A, Von Velthoven V, Augustin HG, Reusch P, Klisch J, Zentner J, Marme D. Significance of VEGF, sFlt-1, and sTie-2 in plasma, serum, and CSF during cerebral ischemia. J. Cereb. Blood Flow Metab. 23: 99-110, 2003
Piossek C, Thierauch KH, Schneider-Mergener J, Volkmer-Engert R, Bachmann MF, Korff T, Augustin HG, Germeroth L. Potent inhibition of angiogenesis by D,L-peptides derived from vascular endothelial growth factor receptor 2. Thromb Haemost. 90: 501-510, 2003
Van Wayenbergh R, Taelman V, Pichon B, Fischer A, Kricha S, Gessler M, Christophe D, Bellefroid EJ. Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse. Dev Dyn 228: 716-725, 2003
Popp H, Kalb R, Fischer A, Lobitz S, Kokemohr I, Hanenberg H, Schindler D. Screening Fanconi anemia lymphoid cell lines of non-A, C, D2, E, F, G subtypes for defects in BRCA2/FANCD1. Cytogenet. Genome Res. 103: 54-57, 2003
Autiero M, Waltenberger J, Communi D, Kranz A, Moons L, Lambrechts D, Kroll J, Plaisance S, De Mol M, Bono F, Kliche S, Fellbrich G, Ballmer-Hofer K, Maglione D, Mayr-Beyrle U, Dewerchin M, Dombrowski S, Stanimirovic D, Van Hummelen P, Dehio C, Hicklin DJ, Persico G, Herbert JM, Shibuya M, Collen D, Conway EM, Carmeliet P. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat. Med. 9: 936-943, 2003
Peitsch W K, Hofmann I, Endlich N, Prätzel S, Kuhn C, Spring H, Gröne H-J, Kriz W, Franke W W.
Kroll J, Cobo P, Sato TN. Versatile inducible activation system of Akt/PKB signaling pathway in mice. Genesis 35: 160-163, 2003.
Christian S, Pilch J, Akerman ME, Porkka K, Laakkonen P, Ruoslahti E. Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels. J. Cell Biol. 163:871-878, 2003 |